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1

Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture

Templeton, Neil, Dean, Jason, Reddy, Pranhitha, Young, Jamey D.

Journal:

Biotechnology and Bioengineering

Year:

2013

Language:

english

File:

PDF, 1.84 MB

english, 2013

2

Application of 13C flux analysis to identify high-productivity CHO metabolic phenotypes

Templeton, Neil, Smith, Kevin D., McAtee-Pereira, Allison G., Dorai, Haimanti, Betenbaugh, Michael J., Lang, Steven E., Young, Jamey D.

Journal:

Metabolic Engineering

Year:

2017

Language:

english

File:

PDF, 1.14 MB

english, 2017

3

Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis

Jamey D. Young, Avantika A. Shastri, Gregory Stephanopoulos, John A. Morgan

Journal:

Metabolic Engineering

Year:

2011

Language:

english

File:

PDF, 1.02 MB

english, 2011

4

Metabolic flux rewiring in mammalian cell cultures

Journal:

Current Opinion in Biotechnology

Year:

2013

Language:

english

File:

PDF, 1014 KB

english, 2013

5

Role of Chinese hamster ovary central carbon metabolism in controlling the quality of secreted biotherapeutic proteins

McAtee, Allison G, Templeton, Neil, Young, Jamey D

Journal:

Pharmaceutical Bioprocessing

Year:

2014

Language:

english

File:

PDF, 1.04 MB

english, 2014

6

13 C flux analysis reveals that rebalancing medium amino acid composition can reduce ammonia production while preserving central carbon metabolism of CHO cell cultures

Pereira, Allison G. McAtee, Walther, Jason L., Hollenbach, Myles, Young, Jamey D.

Journal:

Biotechnology Journal

Year:

2018

Language:

english

File:

PDF, 678 KB

english, 2018

7

Isotopically nonstationary metabolic flux analysis (INST-MFA): putting theory into practice

Cheah, Yi Ern, Young, Jamey D

Journal:

Current Opinion in Biotechnology

Year:

2018

Language:

english

File:

PDF, 803 KB

english, 2018

8

Applications of stable isotope-based metabolomics and fluxomics toward synthetic biology of cyanobacteria

Babele, Piyoosh Kumar, Young, Jamey D.

Journal:

Wiley Interdisciplinary Reviews: Systems Biology and Medicine

Year:

2019

File:

PDF, 3.27 MB

2019

9

Tracing metabolic flux through time and space with isotope labeling experiments

Allen, Doug K, Young, Jamey D

Journal:

Current Opinion in Biotechnology

Year:

2020

File:

PDF, 1.22 MB

2020

10

Toxicant-Induced Metabolic Alterations in Lipid and Amino Acid Pathways Are Predictive of Acute Liver Toxicity in Rats

Pannala, Venkat R., Estes, Shanea K., Rahim, Mohsin, Trenary, Irina, OâBrien, Tracy P., Shiota, Chiyo, Printz, Richard L., Reifman, Jaques, Shiota, Masakazu, Young, Jamey D., Wallqvist, Anders

Journal:

International Journal of Molecular Sciences

Year:

2020

File:

PDF, 3.20 MB

2020

11

An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis

Jamey D. Young, Jason L. Walther, Maciek R. Antoniewicz, Hyuntae Yoo, Gregory Stephanopoulos

Journal:

Biotechnology and Bioengineering

Year:

2008

Language:

english

File:

PDF, 537 KB

english, 2008

12

Integrating cybernetic modeling with pathway analysis provides a dynamic, systems-level description of metabolic control

Jamey D. Young, Kristene L. Henne, John A. Morgan, Allan E. Konopka, Doraiswami Ramkrishna

Journal:

Biotechnology and Bioengineering

Year:

2008

Language:

english

File:

PDF, 355 KB

english, 2008

13

Cybernetic modeling of metabolism: towards a framework for rational design of recombinant organisms

Jamey Young, Kristene Henne, John Morgan, Allan Konopka, Doraiswami Ramkrishna

Journal:

Chemical Engineering Science

Year:

2004

Language:

english

File:

PDF, 238 KB

english, 2004

14

Fluxomers: a new approach for13C metabolic flux analysis

Orr Srour, Jamey D Young, Yonina C Eldar

Journal:

BMC Systems Biology

Year:

2011

Language:

english

File:

PDF, 453 KB

english, 2011

15

On the Matching and Proportional Laws of Cybernetic Models

Jamey D. Young, Doraiswami Ramkrishna

Journal:

Biotechnology Progress

Year:

2007

Language:

english

File:

PDF, 950 KB

english, 2007

16

Corrigendum to “Mapping photoautotrophic metabolism with isotopically nonstationary 13C flux analysis” [Metab. Eng. 13 (2011) 656–665]

Jamey D. Young, Avantika A. Shastri, Gregory Stephanopoulos, John A. Morgan

Journal:

Metabolic Engineering

Year:

2012

Language:

english

File:

PDF, 75 KB

english, 2012

17

Molecular mechanisms and the role of saturated fatty acids in the progression of non-alcoholic fatty liver disease

Leamy, Alexandra K., Egnatchik, Robert A., Young, Jamey D.

Journal:

Progress in Lipid Research

Year:

2013

Language:

english

File:

PDF, 363 KB

english, 2013

18

Isotopically nonstationary 13C flux analysis of Myc-induced metabolic reprogramming in B-cells

Murphy, Taylor A., Dang, Chi V., Young, Jamey D.

Journal:

Metabolic Engineering

Year:

2013

Language:

english

File:

PDF, 838 KB

english, 2013

19

VENTILATION AND BACTERIAL SPREAD IN HOSPITAL

Murphy, Taylor A., Dang, Chi V., Young, Jamey D.

Journal:

Year:

1970

Language:

english

File:

PDF, 312 KB

english, 1970

20

Palmitate-induced Activation of Mitochondrial Metabolism Promotes Oxidative Stress and Apoptosis in H4IIEC3 Rat Hepatocytes

Egnatchik, Robert A., Leamy, Alexandra K., Noguchi, Yasushi, Shiota, Masakazu, Young, Jamey D.

Journal:

Year:

2014

Language:

english

File:

PDF, 1.46 MB

english, 2014

21

The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism

Templeton, Neil, Lewis, Abasha, Dorai, Haimanti, Qian, Elaine A., Campbell, Marguerite P., Smith, Kevin D., Lang, Steven E., Betenbaugh, Michael J., Young, Jamey D.

Journal:

Metabolic Engineering

Year:

2014

Language:

english

File:

PDF, 1.85 MB

english, 2014

22

Tracking cellular metabolomics in lipoapoptosis- and steatosis-developing liver cells

Noguchi, Yasushi, Young, Jamey D., Aleman, Jose O., Hansen, Michael E., Kelleher, Joanne K., Stephanopoulos, Gregory

Journal:

Molecular BioSystems

Year:

2011

Language:

english

File:

PDF, 3.45 MB

english, 2011

23

13C metabolic flux analysis of recombinant expression hosts

Journal:

Current Opinion in Biotechnology

Year:

2014

Language:

english

File:

PDF, 786 KB

english, 2014

24

Isotopically nonstationary 13 C flux analysis of changes in Arabidopsis thaliana leaf metabolism due to high light acclimation

Ma, Fangfang, Jazmin, Lara J., Young, Jamey D., Allen, Doug K.

Journal:

Proceedings of the National Academy of Sciences

Year:

2014

Language:

english

File:

PDF, 941 KB

english, 2014

25

ETA: Robust software for determination of cell specific rates from extracellular time courses

Murphy, Taylor A., Young, Jamey D.

Journal:

Biotechnology and Bioengineering

Year:

2013

Language:

english

File:

PDF, 1.48 MB

english, 2013

26

Editorial overview: Pharmaceutical biotechnology: Engineering cells for high quality biopharmaceuticals production

Junker, Beth H, Young, Jamey D

Journal:

Current Opinion in Biotechnology

Year:

2014

Language:

english

File:

PDF, 239 KB

english, 2014

27

13C flux analysis of cyanobacterial metabolism

Adebiyi, Adeola O., Jazmin, Lara J., Young, Jamey D.

Journal:

Photosynthesis Research

Year:

2015

Language:

english

File:

PDF, 1.40 MB

english, 2015

28

Computational Approaches in Metabolic Engineering

Reed, Jennifer L., Senger, Ryan S., Antoniewicz, Maciek R., Young, Jamey D.

Journal:

Journal of Biomedicine and Biotechnology

Year:

2010

Language:

english

File:

PDF, 116 KB

english, 2010

29

Novel Stable Isotope Analyses Demonstrate Significant Rates of Glucose Cycling in Mouse Pancreatic Islets

Wall, Martha L., Pound, Lynley D., Trenary, Irina, O’Brien, Richard M., Young, Jamey D.

Journal:

Year:

2015

Language:

english

File:

PDF, 966 KB

english, 2015

30

Learning from the Steersman: A Natural History of Cybernetic Models

Young, Jamey D.

Journal:

Industrial & Engineering Chemistry Research

Year:

2015

Language:

english

File:

PDF, 406 KB

english, 2015

31

MID Max: LC–MS/MS Method for Measuring the Precursor and Product Mass Isotopomer Distributions of Metabolic Intermediates and Cofactors for Metabolic Flux Analysis Applications

McCloskey, Douglas, Young, Jamey D., Xu, Sibei, Palsson, Bernhard O., Feist, Adam M.

Journal:

Analytical Chemistry

Year:

2015

Language:

english

File:

PDF, 2.62 MB

english, 2015

32

A modeling method for increased precision and scope of directly measurable fluxes at a genome-scale

McCloskey, Douglas, Young, Jamey D., Xu, Sibei, Palsson, Bernhard Ø., Feist, Adam M.

Journal:

Analytical Chemistry

Year:

2016

Language:

english

File:

PDF, 1013 KB

english, 2016

33

Carbon and Nitrogen Provisions Alter the Metabolic Flux in Developing Soybean Embryos

Doug K. Allen and Jamey D. Young

Journal:

PLANT PHYSIOLOGY

Year:

2013

Language:

english

File:

PDF, 3.21 MB

english, 2013

34

Mass spectrometry-based microassay of 2 H and 13 C plasma glucose labeling to quantify liver metabolic fluxes in vivo

Hasenour, Clinton M., Wall, Martha L., Ridley, D. Emerson, Hughey, Curtis C., James, Freyja D., Wasserman, David H., Young, Jamey D.

Journal:

AJP Endocrinology and Metabolism

Year:

2015

Language:

english

File:

PDF, 2.10 MB

english, 2015

35

Knockdown of Triglyceride Synthesis Does Not Enhance Palmitate Lipotoxicity or Prevent Oleate-Mediated Rescue in Rat Hepatocytes

Leamy, Alexandra K., Hasenour, Clinton M., Egnatchik, Robert A., Trenary, Irina A., Yao, Conghui, Patti, Gary J., Shiota, Masakazu, Young, Jamey D.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids

Year:

2016

Language:

english

File:

PDF, 693 KB

english, 2016

36

Oncogenic KRAS and BRAF drive metabolic reprogramming in colorectal cancer

Hutton, Josiah E., Wang, Xiaojing, Zimmerman, Lisa J., Slebos, Robbert J.C., Trenary, Irina A., Young, Jamey D., Li, Ming, Liebler, Daniel C.

Journal:

Molecular & Cellular Proteomics

Year:

2016

Language:

english

File:

PDF, 2.23 MB

english, 2016

37

Dependence On Glycolysis Sensitizes BRAF-mutated Melanomas For Increased Response To Targeted BRAF Inhibition

Hardeman, Keisha N., Peng, Chengwei, Paudel, Bishal B., Meyer, Christian T., Luong, Thong, Tyson, Darren R., Young, Jamey D., Quaranta, Vito, Fessel, Joshua P.

Journal:

Scientific Reports

Year:

2017

Language:

english

File:

PDF, 1.51 MB

english, 2017

38

Isotopically nonstationary 13 C flux analysis of cyanobacterial isobutyraldehyde production

Jazmin, Lara J., Xu, Yao, Cheah, Yi Ern, Adebiyi, Adeola O., Johnson, Carl Hirschie, Young, Jamey D.

Journal:

Metabolic Engineering

Year:

2017

Language:

english

File:

PDF, 705 KB

english, 2017

39

Loss of hepatic AMP-activated protein kinase impedes the rate of glycogenolysis but not gluconeogenic fluxes in exercising mice

Hughey, Curtis C., James, Freyja D., Bracy, Deanna P., Donahue, E. Patrick, Young, Jamey D., Viollet, Benoit, Foretz, Marc, Wasserman, David H.

Journal:

Journal of Biological Chemistry

Year:

2017

Language:

english

File:

PDF, 4.50 MB

english, 2017

40

Biochemical and Metabolic Engineering Approaches to Enhance Production of Therapeutic Proteins in Animal Cell Cultures

Templeton, Neil, Young, Jamey D.

Journal:

Biochemical Engineering Journal

Year:

2018

Language:

english

File:

PDF, 755 KB

english, 2018

41

The TLR4 Agonist Monophosphoryl Lipid A Drives Broad Resistance to Infection via Dynamic Reprogramming of Macrophage Metabolism

Fensterheim, Benjamin A., Young, Jamey D., Luan, Liming, Kleinbard, Ruby R., Stothers, Cody L., Patil, Naeem K., McAtee-Pereira, Allison G., Guo, Yin, Trenary, Irina, Hernandez, Antonio, Fults, Jessic

Journal:

The Journal of Immunology

Year:

2018

Language:

english

File:

PDF, 2.74 MB

english, 2018

42

Metabolic network-based predictions of toxicant-induced metabolite changes in the laboratory rat

Pannala, Venkat R., Wall, Martha L., Estes, Shanea K., Trenary, Irina, O’Brien, Tracy P., Printz, Richard L., Vinnakota, Kalyan C., Reifman, Jaques, Shiota, Masakazu, Young, Jamey D., Wallqvist, Ander

Journal:

Scientific Reports

Year:

2018

Language:

english

File:

PDF, 2.44 MB

english, 2018

43

The Role of Pool Size Measurements in Improving Flux Estimations in Non-Stationary Metabolic Flux Analysis

Sher, Anna, Fridman, Daniel, Young, Jamey, Musante, Cynthia J.

Journal:

Biophysical Journal

Year:

2019

Language:

english

File:

PDF, 42 KB

english, 2019

44

Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat

Vinnakota, Kalyan C., Pannala, Venkat R., Wall, Martha L., Rahim, Mohsin, Estes, Shanea K., Trenary, Irina, O’Brien, Tracy P., Printz, Richard L., Reifman, Jaques, Shiota, Masakazu, Young, Jamey D., W

Journal:

Frontiers in Physiology

Year:

2019

Language:

english

File:

PDF, 1.53 MB

english, 2019

45

Genome-scale model-based identification of metabolite indicators for early detection of kidney toxicity

Pannala, Venkat R, Vinnakota, Kalyan C, Estes, Shanea K, Trenary, Irina, OˈBrien, Tracy P, Printz, Richard L, Papin, Jason A, Reifman, Jaques, Oyama, Tatsuya, Shiota, Masakazu, Young, Jamey D, Wallqvi

Journal:

Toxicological Sciences

Year:

2019

Language:

english

File:

PDF, 2.28 MB

english, 2019

46

Genome-scale model-based identification of metabolite indicators for early detection of kidney toxicity

Pannala, Venkat R, Vinnakota, Kalyan C, Estes, Shanea K, Trenary, Irina, OˈBrien, Tracy P, Printz, Richard L, Papin, Jason A, Reifman, Jaques, Oyama, Tatsuya, Shiota, Masakazu, Young, Jamey D, Wallqvi

Journal:

Toxicological Sciences

Year:

2019

File:

PDF, 2.28 MB

2019

47

Simultaneous tracers and a unified model of positional and mass isotopomers for quantification of metabolic flux in liver

Deja, Stanislaw, Fu, Xiaorong, Fletcher, Justin A., Kucejova, Blanka, Browning, Jeffrey D., Young, Jamey D., Burgess, Shawn C.

Journal:

Metabolic Engineering

Year:

2020

File:

PDF, 2.99 MB

2020

48

Vitamin E does not prevent Western dietâinduced NASH progression and increases metabolic flux dysregulation in mice

Hasenour, Clinton M., Kennedy, Arion J., Bednarski, Tomasz, Trenary, Irina A., Eudy, Brandon J., DaSilva, Robin P, Boyd, Kelli L., Young, Jamey D.

Journal:

The Journal of Lipid Research

Year:

2020

Language:

english

File:

PDF, 1.98 MB

english, 2020

49

Systematic identification and elimination of flux bottlenecks in the aldehyde production pathway of Synechococcus elongatus PCC 7942

Cheah, Yi Ern, Xu, Yao, Sacco, Sarah A., Babele, Piyoosh K., Zheng, Amy O., Johnson, Carl Hirschie, Young, Jamey D.

Journal:

Metabolic Engineering

Year:

2020

File:

PDF, 4.59 MB

2020

50

Host nutrient milieu drives an essential role for aspartate biosynthesis during invasive Staphylococcus aureus infection

Potter, Aimee D., Butrico, Casey E., Ford, Caleb A., Curry, Jacob M., Trenary, Irina A., Tummarakota, Srivarun S., Hendrix, Andrew S., Young, Jamey D., Cassat, James E.

Journal:

Proceedings of the National Academy of Sciences

Year:

2020

File:

PDF, 851 KB

2020

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